Hot topics from the Assemblies
ثبت نشده
چکیده
Authors: Uzun S, Djamin RS, Kluytmans JAJW, et al. Lancet Respir Med 2014; 2: 361–368 Summary: This study represents a significant development in the use of long-term azithromycin maintenance treatment in a subgroup of patients with chronic obstructive pulmonary disease (COPD). Patients with .3 exacerbations in the preceding year were randomised to receive thrice-weekly placebo or azithromycin treatment. 92 patients were randomised to receive azithromycin (n547) or placebo (n545) and reviewed every 3 months for 1 year. The primary outcome was rate of exacerbations. The statistically significant reduction in exacerbations in patients treated with azithromycin was sustained after adjustment for covariates. The rate ratio of exacerbations with azithromycin to placebo was 0.58 (95% CI 0.42–0.79; p50.001). Median time to first exacerbation was 59 days with placebo (95% CI 31–87) and 130 days with azithromycin (CI 28-232; p50.001). The odds ratio for hospital admission did not differ between groups (OR 1.34, 95% CI 0.67–2.70; p50.41). In terms of quality-of-life measures (St Georges Respiratory Questionnaire and SF-12) there was a difference in favour of azithromycin at 3 months which was not maintained at 12-month follow up. The most commonly reported side effect of diarrhoea was more prevalent in the azithromycin group (p50.015). Fewer patients in the azithromycin group had colonisation with new respiratory pathogens. This study has significant implications for clinical practice. The authors recommend long-term azithromycin treatment in patients with COPD, refractory to standard care, although they caution in favour of monitoring for macrolide resistance. Risks of macrolide resistance and exposure to side effects can be minimised through targeted therapy to this subgroup of patients. Reviewed by: Serena Strickland (UK, Assembly 1)
منابع مشابه
Detecting and Tracking The Real-time Hot Topics: A Study on Computational Neuroscience
In this study, following the idea of our previous paper (Wang, et al., 2013a), we improve the method to detect and track hot topics in a specific field by using the real-time article usage data. With the “usage count” data provided by Web of Science, we take the field of computational neuroscience as an example to make analysis. About 10 thousand articles in the field of Computational Neuroscie...
متن کاملStudy on Hot Topic Discovery from Chinese Texts
With the development of information technology, there has been an increased popularity in the use of electronic texts. Topic detection and tracking can identify hot information from isolated texts. Obtaining hot topics has become an important issue in recent years. The combination of statistics and natural language processing was utilized in the current study to discover hot topics from texts. ...
متن کاملRe-Evaluation of On-Line Hot Topic Discovery Model
The web has become indispensible part of modern life and has unbelievable influence in our real society. It spreads and provides sources of hundreds of millions of news and information, in which some topics that are growing in interest over time have great impact on our real life, sometimes even affect the development of events in a way. In order to pick out these influencing news and topics on...
متن کاملHot Topic Detection in News Blogs from the Perspective of W2T
News blog hot topics are important for the information recommendation service and marketing. However, information overload and personalized management make the information arrangement more difficult. Moreover, what influences the formation and development of blog hot topics is seldom paid attention to. In order to correctly detect news blog hot topics, the paper first analyzes the development o...
متن کاملDo scientists trace hot topics?
Do scientists follow hot topics in their scientific investigations? In this paper, by performing analysis to papers published in the American Physical Society (APS) Physical Review journals, it is found that papers are more likely to be attracted by hot fields, where the hotness of a field is measured by the number of papers belonging to the field. This indicates that scientists generally do fo...
متن کامل